Serotonin Alters the Phase Equilibrium of a Ternary Mixture of Phospholipids and Cholesterol
Unsaturated and saturated phospholipids tend to laterally segregate, especially in the presence of cholesterol.Small molecules such as neurotransmitters, toxins, drugs etc.possibly modulate this lateral segregation.The small aromatic neurotransmitter serotonin (5-HT) has been found to bind to membranes.We studied the lipid structure and packing of